At DNA Nanobots, we are redefining the boundaries of medicine and material science through our proprietary platform.
We are currently looking for meticulous, process-oriented scientists to join our in-person team in Powell, OH.
Current Job Postings
Cloning & Scaffold Engineering Scientist
Location: Powell, OH [In-Person]
Type: Full-Time
Reports to: Chris Lucas, [Chief Science Officer]
Core Responsibilities
Vector Engineering & Cloning Operations
- Lead High-Throughput Workflows: Drive cloning operations including Gibson Assembly, restriction cloning, promoter swaps, and linker integration.
- Validation & QC: Perform rigorous construct validation via PCR, NGS/Sanger sequencing, and specialized QC assays to ensure nanobot integrity.
- Inventory Management: Maintain a meticulous construct inventory and update all cloning documentation to support downstream teams.
Phage & ssDNA Production
- Execution: Lead plasmid preps, coordinate helper-plasmids, and manage complex phagemid setups.
- Scale-up: Assist in the critical transition of scaffold DNA production from batch-to-pilot scale.
- Readiness: Ensure constant availability of plasmids and phagemids to support DNA Origami builds.
Cloning Program Management
- Strategic Coordination: Align cloning timelines across internal R&D teams and external partners.
- Project Tracking: Lead planning calls, maintain shared task lists, and track progress to ensure hit rates meet R&D assay deadlines.
Analytical & Molecular Support
- Troubleshooting: Provide expert data interpretation and solve complex cloning-associated challenges.
- Cross-Functional Collaboration: Work closely with the Molecular Biology team to ensure all constructs are “assay-ready.”
- Payload Development: Support the design and engineering of genetically encoded payloads for nanobot delivery.
Who You Are
- Technical Expert: You have deep experience in molecular cloning and a passion for DNA nanotechnology or synthetic biology.
- Process-Oriented: You enjoy building “engines” – standardizing workflows to make them faster and more reliable.
- Collaborative: You thrive in shared roles and enjoy working across teams (from Phage production to Analytical support).
- Organized: You can manage complex timelines and keep external partners on track without breaking a sweat.
Required Qualifications
- Ph.D. or Master’s degree in Molecular Biology, Bioengineering, Synthetic Biology, or a related field OR at least 3-5 years of relevant laboratory experience.
- Hands-on expertise with Gibson Assembly and Phage display/ssDNA production.
- Experience with DNA Origami or scaffold-based nanostructures is highly preferred.
DNA Origami Production Scientist
Location: Powell, OH [In-Person]
Type: Full-Time
Reports to: Patrick Halley, [Chief Technology Officer]
Core Responsibilities
DNA Origami Assembly & Functionalization
- Execute Core Workflows: Lead the folding, annealing, and purification of complex DNA origami structures.
- Precision Functionalization: Perform oligo-based functionalization according to established Standard Operating Procedures (SOPs).
- Product Improvement: Support the development of stability, yield, and formulation improvements to enhance nanobot performance.
Phage/ssDNA Production
- Scaffold Amplification: Conduct batch- and pilot-scale phage amplification to produce high-quality scaffold DNA.
- Downstream Processing: Perform PEG precipitation, filtration steps, and ssDNA QC gels.
- Pipeline Integration: Work closely with the cloning scientists to coordinate scaffold production schedules and ensure material availability.
Process Optimization & Documentation
- Workflow Refinement: Improve the reproducibility, yield, and “error-proofing” of origami assembly workflows.
- Scalability: Help build manufacturing-aligned SOPs to prepare the platform for future large-scale production.
- Quality Excellence: Maintain rigorous documentation of all production activities to ensure traceability and data integrity.
Cross-Functional Coordination
- Assay Support: Partner with the Molecular Biology team to ensure that nanostructures are ready and available for critical assays.
- Strategic Planning: Attend platform planning meetings and communicate production timelines to executives and stakeholders.
- Design Troubleshooting: Coordinate directly with Chief Technology Officer on design requirements and troubleshooting technical challenges.
Who You Are
- Meticulous Scientist: You have an eye for detail and a “right-first-time” mentality when it comes to complex molecular assemblies.
- Process Innovator: You don’t just follow protocols; you look for ways to make them more efficient, scalable, and reproducible.
- Collaborative Partner: You enjoy working in a fast-paced team environment where communication with cloning and assay teams is vital.
Required Qualifications
- Ph.D. or Master’s degree in Molecular Biology, Bioengineering, Synthetic Biology, or a related field OR at least 3-5 years of relevant laboratory experience.
- Hands-on experience with DNA origami folding and purification techniques (e.g., PEG precipitation, HPLC, or gel extraction).
- Familiarity with ssDNA production and phage-based systems.
- Strong background in creating and maintaining SOPs for laboratory processes.
